How Should We Respond to Science Denialists?

Why Most Published Research Findings Are False
Improving transparency and scientific rigor in  academic publishing
Offline: What is medicine’s 5 sigma?
WHY MOST PUBLISHED FINDINGS ARE FALSE: REVISITING THE IOANNIDIS ARGUMENT
Believe It Or Not, Most Published Research Findings Are Probably False
The science is clear, studies are usually wrong.  The findings have been peer reviewed, the gold standard in scientific research, even though the peer review process is a joke.
What an Audacious Hoax Reveals About Academia
Stop denying the science.  Scientific research has demonstrated beyond question that scientific research is usually wrong.

All of the references you quoted are taken from extreme publications, They are extreme and bias and at best, say absolutely nothing.

For example, the very first sentence of the first article, "There is increasing concern that most current published research findings are false." alludes to concern by who? We don't know and the sentence in effect, says nothing.

The same article says, "Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias.".... the operative words being "many current" and "may often" . It asserts nothing at all.

In another article, again, the author writes the same non-committal suggestions with no evidence, irrelevant evidence or simply mild suggestions without actually saying anything. The only thing he did actually assert was "I’m certainly not immune myself from credulously accepting research that has later been called into question". He is generalising and doesn't quote an example however what is relevant is his admission which I think reveals the answer to the debate.

The answer I think is that people of a certain disposition will take things at face value and expect that all other people do so. They will not explore the possibilities, weigh up the evidence then make informed conclusions.

Trying to conflate "many scientific experiments fail" with "most published research results are probably false" is wrong and incorrect. Thomas Edison conducted and published nearly one thousand failed experiments before he conclusively found the correct result that lead to the invention of the light bulb. Similarly, almost everything that we use in society today is the result of concise, irrefutable scientific research.

In his book "The Greatest Show On Earth", Richard Dawkins concisely and accurately tables the scientific findings that conclusively overturn any idea of creation of life. To date, not one of those findings has been proven wrong and even if a finding were to be found to be wrong the overwhelming number of other findings still support the irrefutable fact that life evolved through natural selection; there being no evidence nor reason for a third-party intervention.

So, could it be that this debate also raises the suspicion that those who resort to extreme (and therefore, wrong) evidence are desperately grasping at straws in order to not let go of desperately extreme beliefs?